The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: New ways of targeting monocytes to treat infection and cancer

Mueller Group

Immune responses are initiated in lymphoid tissues such as the spleen and lymph nodes. Monocytes are polyvalent cells that can differentiate into inflammatory dendritic cells or macrophages following an injury or infection. In diseases such as cancer and chronic infection, monocytes differentiate into suppressive cells that inhibit immune responses. How monocytes are recruited into the spleen or lymph nodes and contribute to protection from infection is not fully understood. We recently found that fibroblasts express chemokines responsible for the recruitment of monocytes. This project will investigate how fibroblasts direct protective and pathogenic monocyte responses following infection and cancer. We will use a new mouse model that disrupt the fibroblast/monocyte crosstalk, infectious models and cancer, flow cytometry and confocal imaging.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Yannick Alexandre

Project Co-supervisor

Professor Scott Mueller

Project availability
Master of Biomedical Science

Mueller Group

5 vacancies

Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mueller group is focused on examining immune responses and nervous system interactions during acute and chronic viral infections and in cancer. We are seeking a fundamental understanding of biology and new treatments for disease. We are using state-of-the-art methods, including advanced microscopy, spectral flow cytometry, single cell sequencing and bioinformatics.

Mueller Group Current Projects