The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Molecular basis for growth factor surveillance in natural killer and innate lymphoid cells

Barrow group

We have recently shown the activating ITAM receptor NKp44 drives cancer immuno-surveillance by sensing platelet-derived growth factor (PDGF)-D. PDGF-D engagement of NKp44 triggered IFN-γ and TNF-α secretion from NK cells and ILC1 and TNF-α secretion from ILC3, which induced tumour cell growth arrest. Interestingly, several alternatively spliced NKp44 transcripts have been reported including an ITIM-encoding NKp44 isoform that is predicted to be inhibitory and is associated with poor prognosis in cancer. This project aims to determine the expression and modes of signalling of the different NKp44 isoforms in NK cells, ILC1 and ILC3 and how th 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Alexander Barrow

Project Co-supervisor

Dr Andrew Brooks

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Barrow group

[email protected]

2 vacancies

Themes
Host Pathogens Interactions
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

The Barrow group is interested in a new avenue of immunological research termed growth factor surveillance. Growth factors (GFs) are over-expressed by tumours to promote angiogenesis, stromal reaction and tumour growth. Moreover, many viruses encode GFs that are required for viral infectivity in vivo. The goal of our lab is to understand how GF surveillance receptors control immune responses to tumours and pathogens with the ultimate aim of identifying critical nodes in these pathways that can be exploited for cancer immunotherapy and vaccine development. 


Barrow group Current Projects