The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Mining The Cancer Genome Atlas (TCGA) to identify novel tumour surveillance pathways and targets for immune checkpoint blockade.

Barrow group

The Cancer Genome Atlas (TCGA) is a cancer genomics program that has molecularly characterized over 20,000 primary cancers and matched normal samples spanning 33 cancer types. However, immune surveillance pathways associated with a favourable anti-cancer immunity for the many different cancers remains unknown. Moreover, immune pathways that are detrimental to patient survival that could be potentially blocked to promote anti-cancer immunity and exploited for cancer immunotherapy remain to be identified. This project will use in silico methods to identify novel immune surveillance pathways and molecular targets that can be exploited for immune checkpoint blockade in cancer.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Alexander David Barrow

Project Co-supervisor

Stefano Mangiola

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Barrow group

[email protected]

3 vacancies

Themes
Immunology
Viral Infectious Diseases
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Translational and Clinical Research

The Barrow group is interested in innate immune recognition programs, in particular a new immunological recognition strategy termed ‘growth factor surveillance’. Growth factors (GFs) are over-expressed by cancer cells to promote tumour growth. We first showed that the immune system evolved activating receptors to sense aberrant GF expression by cancers. The Barrow group’s goal is to understand how the immune system recognises GF expression by tumours with the ultimate aim of exploiting these pathways for cancer immunotherapy and the development of new cancer immunotherapies.


Barrow group Current Projects