Project: Mapping the impact of antibody and B cell memory on secondary antigen exposure
Boosting immunity established by prior infection or previous vaccines is complex, with differential contributions from naïve and memory B cells, and the impact of pre-existing antibody. This projects seeks to use transgenic mouse models to map the kinetics and localisation of immune lymphocytes during secondary antigen exsposures.
The Wheatley group is interested in factors that program broad and durable humoural immunity against infectious pathogens such as SARS-CoV2 and influenza. Our research involves immunological charactersiaton of B cells and antibodies, development of assays and tools to study antiviral immunity, novel vaccine design and the development of monoclonal antibodies to treat or prevent infections.