The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Mapping elemental fluxes during host-pathogen interaction

McDevitt group

During infection, the body modulates the concentrations of essential metal ions to prosecute antimicrobial activity and aid immune clearance of the pathogen. This project will investigate which inorganic elements change in abundance during infection by using next generation laser ablation inductively coupled plasma-mass spectrometry to directly image infected tissues. How these changes impact bacterial pathogens will then be examined using a suite of fluorescently tagged reporter strains that have altered metal handling properties. Through these approaches this project will reveal the interplay between pathogenic bacteria and inorganic chemical components at the host-pathogen interface.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Christopher McDevitt 

Project Co-supervisor

Professor Philip Doble 

Project availability
PhD/MPhil
Honours

McDevitt group

christopher.mcdevitt@unimelb.edu.au

2 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research

Research in the McDevitt group seeks to understand how bacterial pathogens acquire and use metal ions and how this shapes the host-pathogen interaction during infection.