Project: Investigating host factors that control the replication of respiratory viruses
Reading Group
In addition to influenza A virus (IAV), members of the Paramyxoviridae family cause significant respiratory disease in humans. These include mumps virus (MuV), human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) and parainfluenza viruses (PIV). We have expertise in generating cell lines that overexpress proteins that have been widely implicated in (i) viral entry into host cells and (ii) restriction of viral replication in host cells. We will use these techniques to determine if particular host factors interfere with respiratory virus infection of mammalian cells.
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Reading Group
2 vacancies
The Reading Group have expertise in understanding viral attachment factors, cellular receptors and entry pathways, virus-induced activation of host genes and the mechanisms by which intracellular host proteins can block virus replication.
Our current research is focussed on
(i) understanding the entry pathways and viral life cycle of respiratory viruses in host epithelial cells and immune cells
(ii) investigating host factors (viral restriction factors such as interferon stimulated genes) that control the replication of respiratory viruses in epithelial cells vs immune cells.
Reading Group Current Projects
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Investigating host factors that control the replication of respiratory viruses
PhD/MPhil, Master of Biomedical Science
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Understanding the entry pathways and viral life cycle of influenza A virus (IAV) in host epithelial cells and immune cells
PhD/MPhil, Master of Biomedical Science
Research degrees at the Doherty Institute are administered by the University of Melbourne.