The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Improving the formation of protective immunity against human viruses

Villadangos Group

CD4+ helper T cells underpin the generation of life-long protective immunity against infectious disease. They are pivotal for activating CD8+ killer T cells and driving B cell production of neutralising antibodies, which are both required to recover from and prevent infection. However, the CD4+ T cells that are activated following infection are not generally assessed in studies of vaccine efficacy and/or protective immunity. In addition to established functions of effector CD4+ T cells in driving immune memory is an emerging role for regulatory T cells (Tregs), which until now have been under-appreciated in this context. Tregs, in addition to their critical role in maintaining self-tolerance, are important in limiting immunopathology following infection. Further, evidence from mouse studies suggests Tregs are crucial for the generation of memory T cells and also control the homing of immune cells into infected tissues. However, it remains unknown if these are also key functions for human Tregs. This project will investigate the mechanisms of how human Tregs shape immune memory responses using cutting-edge technology including organoid co-culture, gene editing, functional cellular assays and spectral cytometry. Data from this project will form a foundation for designing more efficacious treatment and prevention strategies for infectious diseases.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Jose Villadangos

Project Co-supervisor

Dr Laura Cook

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Villadangos Group

[email protected]

3 vacancies

Themes
Immunology
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Translational and Clinical Research

The Villadangos group studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumour antigens to T cells by dendritic cells, B cells and macrophages. We are characterising the development, regulation and impairment of antigen presenting cells by pathogens, inflammatory mediators and tumours. We are also dissecting the biochemical machinery involved in antigen capture, processing and presentation. We use this knowledge to understand how T cell-dependent immunity is initiated and maintained, and apply it to design better vaccines and immunotherapies against infectious agents and cancer.


Villadangos Group Current Projects