Project: Immunosurveillance pathways in brain cancer
Barrow group
Growth factor (GF) surveillance is a new mode of cancer immunosurveillance in which the immune system responds to GFs over-expressed by cancers and infected cells. Our work has implicated natural killer (NK) cells and GF surveillance in the control of glioblastoma, a high-grade glioma with poor survival. In collaboration with the Mantamadiotis group, the Barrow group is assessing the role of NK cells and other immune cell subsets in immunosurveillance of the brain using a transgenic mouse model of glioma.
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Barrow group
3 vacancies
The Barrow group is interested in a new avenue of immunological research termed growth factor surveillance. Growth factors (GFs) are over-expressed by tumours to promote angiogenesis, stromal reaction and tumour growth. Moreover, many viruses encode GFs that are required for viral infectivity in vivo. The goal of our lab is to understand how GF surveillance receptors control immune responses to tumours and pathogens with the ultimate aim of identifying critical nodes in these pathways that can be exploited for cancer immunotherapy and vaccine development.
Barrow group Current Projects
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Molecular basis for growth factor surveillance in natural killer cells
PhD/MPhil, Master of Biomedical Science, Honours
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Molecular basis for growth factor immune-surveillance in plasmacytoid dendritic cells
PhD/MPhil, Master of Biomedical Science, Honours
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Immunosurveillance pathways in brain cancer
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.