The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Immunosurveillance pathways in brain cancer

Barrow group

Growth factor (GF) surveillance is a new mode of cancer immunosurveillance in which the immune system responds to GFs over-expressed by cancers and infected cells. Our work has implicated natural killer (NK) cells and GF surveillance in the control of glioblastoma, a high-grade glioma with poor survival. In collaboration with the Mantamadiotis group, the Barrow group is assessing the role of NK cells and other immune cell subsets in immunosurveillance of the brain using a transgenic mouse model of glioma.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Alexander David Barrow

Project Co-supervisor

Dr Theo Mantamadiotis

Project availability
Master of Biomedical Science

Barrow group

[email protected]

3 vacancies

Host Pathogens Interactions
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

The Barrow group is interested in a new avenue of immunological research termed growth factor surveillance. Growth factors (GFs) are over-expressed by tumours to promote angiogenesis, stromal reaction and tumour growth. Moreover, many viruses encode GFs that are required for viral infectivity in vivo. The goal of our lab is to understand how GF surveillance receptors control immune responses to tumours and pathogens with the ultimate aim of identifying critical nodes in these pathways that can be exploited for cancer immunotherapy and vaccine development. 

Barrow group Current Projects