The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Immunosurveillance pathways in brain cancer

Barrow group

Growth factor (GF) surveillance is a new mode of cancer immunosurveillance in which the immune system responds to GFs over-expressed by cancers and infected cells. Our work has implicated natural killer (NK) cells and GF surveillance in the control of glioblastoma, a high-grade glioma with poor survival. In collaboration with the Mantamadiotis group, the Barrow group is assessing the role of NK cells and other immune cell subsets in immunosurveillance of the brain using a transgenic mouse model of glioma.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Alexander David Barrow

Project Co-supervisor

Dr Theo Mantamadiotis

Project availability
Master of Biomedical Science

Barrow group

3 vacancies

Viral Infectious Diseases
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Translational and Clinical Research

The Barrow group is interested in innate immune recognition programs, in particular a new immunological recognition strategy termed ‘growth factor surveillance’. Growth factors (GFs) are over-expressed by cancer cells to promote tumour growth. We first showed that the immune system evolved activating receptors to sense aberrant GF expression by cancers. The Barrow group’s goal is to understand how the immune system recognises GF expression by tumours with the ultimate aim of exploiting these pathways for cancer immunotherapy and the development of new cancer immunotherapies.

Barrow group Current Projects