The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Identifying mechanisms that control maintenance and function of CD4 T cells in cancer

Kallies Group

We have found that long-term CD4 T cell immunity is maintained by stem-like cells that act as precursors to different helper cell lineages and respond to therapeutic intervention such as checkpoint inhibition. In this project, we will use novel mouse models and cutting-edge molecular methods to examine the factors that control differentiation and function of these cells in the context of cancer progression and therapy including checkpoint inhibition and mRNA vaccination. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Axel Kallies

Project Co-supervisor

Dr Carlson Tsui

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Kallies Group

axelk@unimelb.edu.au

3 vacancies

Themes
Immunology
Viral Infectious Diseases
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Clinical and health systems research

Our group has done pioneering work in understanding the role of immune cells in infection, metabolic diseases and cancer. In particular, our laboratory has discovered key molecules and pathways that regulate the differentiation and function of of T cells, including cytotoxic CD8, CD4 and regulatory T cells in viral infection, cancer and type 2 diabetes.