Project: Identifying mechanisms that control maintenance and function of CD4 T cells in cancer
Kallies Group
We have found that long-term CD4 T cell immunity is maintained by stem-like cells that act as precursors to different helper cell lineages and respond to therapeutic intervention such as checkpoint inhibition. In this project, we will use novel mouse models and cutting-edge molecular methods to examine the factors that control differentiation and function of these cells in the context of cancer progression and therapy including checkpoint inhibition and mRNA vaccination.
Contact project supervisor for further
information and application enquiries
Kallies Group
3 vacancies
Our group has done pioneering work in understanding the role of immune cells in infection, metabolic diseases and cancer. In particular, our laboratory has discovered key molecules and pathways that regulate the differentiation and function of of T cells, including cytotoxic CD8, CD4 and regulatory T cells in viral infection, cancer and type 2 diabetes.
Kallies Group Current Projects
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Understanding the heterogeneity of intestinal resident memory T cells (TRMs) and their role in homeostasis
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding how metabolism and nutrient signaling regulate intestinal tissue resident memory T cells development and function
PhD/MPhil, Master of Biomedical Science, Honours
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Dissecting the role of tissue regulatory T cells in the development of memory T cells during infection and cancer.
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding factors that regulate T cell stemness in cancer and chronic disease
PhD/MPhil, Master of Biomedical Science, Honours
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Identifying mechanisms that control maintenance and function of CD4 T cells in cancer
PhD/MPhil, Master of Biomedical Science, Honours
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Understanding how regulatory T cells (Tregs) control cancer and chronic disease
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.