Project: Identifying immunosuppressive mechanisms in brain cancer
Determining the best immunotherapy which could be applied to a specific cancer type requires a deep understanding of the immunobiology of the tumour tissue. This project aims to understand the types and distribution of specific cells and histopathological properties in brain tumour tissue, and how the tumour microenvironment, including immune cells, contribute to oncogenesis. Unique brain cancer cell lines and brain tumour tissue from animal models and patients will be used to investigate the tumour microenvironment using state-of-the-art multiplex immunohistochemistry and computational analysis. This project would suit students interested in learning and applying computational analysis toward analysis of the tumour microenvironment.
The Mantamadiotis group’s research aims to understand how the tumor microenvironment, including immune cells, contribute to oncogenesis and how to modulate the immune system to improve current brain cancer therapy.
Mantamadiotis group Current Projects
PhD/MPhil, Master of Biomedical Science, Honours