The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: How infection and trauma cause dendritic cell paralysis and lethal immunosuppression

Villadangos Group

The goal of this project is to characterise the mechanisms that cause DC paralysis and investigate therapies to prevent immunosuppression post-SIRS.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Jose Villadangos

Project Co-supervisor

Dr Justine Mintern

Project availability
Honours

Villadangos Group

j.villadangos@unimelb.edu.au

3 vacancies

Themes
Immunology
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Translational and Clinical Research

The Villadangos group studies the first event that triggers adaptive immune responses: the presentation of pathogen or tumour antigens to T cells by dendritic cells, B cells and macrophages. We are characterising the development, regulation and impairment of antigen presenting cells by pathogens, inflammatory mediators and tumours. We are also dissecting the biochemical machinery involved in antigen capture, processing and presentation. We use this knowledge to understand how T cell-dependent immunity is initiated and maintained, and apply it to design better vaccines and immunotherapies against infectious agents and cancer.