Project: How does virulence work in Klebsiella pneumoniae
This project will explore novel aspects of regulation by the bacterium – how the bacterial capsule is retained, how it is lost and whether retention is sensitive to antibody-mediated inhibition. The project will involve laboratory experiments, infections into tissue culture cells, analysis of proteins and DNA, some sequencing and sequence analysis using bioinformatics.
The Strugnell Lab has two major research interests. Firstly, in driving immunity to Salmonella spp. Infections in humans and in mice through vaccination and natural infection, and in studying and quantifying this immunity in laboratory assays, from CD4+ T cells, to antibodies. The other major interest is in Klebsiella pneumoniae, an encapsulated opportunistic pathogen that readily forms biofilms. We are keen to understand how virulence works in K. pneumoniae and how it is regulated. This includes genes and processes required for capsule retention and regulation through novel mechanisms. These research interests both involved collaborations with Germany.