Project: How do lymph nodes facilitate cancer metastasis?
This project will examine the bi-directional interactions between metastatic tumour cells and the lymphoid organs, in order to define how cancer impacts tissue functions, and identify mechanisms to restrict tumour growth and improve disease outcomes.
Research in the Mueller group is focused on examining immune responses to acute and chronic viral infections and to tumours. We are using state-of-the-art methods, including intravital 2-photon microscopy to visualise immune cells and pathogens in real time. We are examining how T cells are activated and protect against infections, the induction of immune memory and tissue-resident memory T cells, and the role of stromal cells and nerves in tissues for the design of new vaccines and therapeutics.