Project: Harnessing the lymph nodes to treat cancer metastasis
Mueller Group
Metastasis is responsible for most cancer deaths, and new treatments are urgently needed against metastatic disease. Tumour cells use lymph nodes to spread around the body, but how this occurs is not clear. This project will examine how metastatic tumour cells corrupt lymph nodes and use this to spread. We will examine immune responses and stromal cells known as cancer associated fibroblasts to identify new ways to improve disease outcomes. Techniques used in this work include advanced spectral imaging and spectral flow cytometry, single cell RNA sequencing and spatial transcriptomics, custom imagage analysis tools and bioinformtics.
Contact project supervisor for further
information and application enquiries
Mueller Group
5 vacancies
Research in the Mueller group is focused on examining immune responses and nervous system interactions during acute and chronic viral infections and in cancer. We are seeking a fundamental understanding of biology and new treatments for disease. We are using state-of-the-art methods, including advanced microscopy, spectral flow cytometry, single cell sequencing and bioinformatics.
Mueller Group Current Projects
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Neural regulation of anti-cancer immunity
PhD/MPhil, Master of Biomedical Science, Honours
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Harnessing the lymph nodes to treat cancer metastasis
PhD/MPhil, Master of Biomedical Science, Honours
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Targeting stem-like T cell niches to treat chronic infections
PhD/MPhil, Master of Biomedical Science, Honours
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New ways of targeting monocytes to treat infection and cancer
PhD/MPhil, Master of Biomedical Science, Honours
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Neuroimmune interactions in virus infection
PhD/MPhil, Master of Biomedical Science
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Deep learning approaches to track immune cell migration in vivo
PhD/MPhil
Research degrees at the Doherty Institute are administered by the University of Melbourne.