The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: How do fibroblasts regulate immune response during infection?

Mueller Group
Immune responses are initiated in lymphoid tissues such as the spleen and lymph nodes. Monocytes are polyvalent cells that can differentiate into inflammatory dendritic cells or macrophages following an injury or infection. How monocytes are recruited into the spleen or lymph nodes and contribute to protection from infection is not fully understood. We recently found that fibroblasts express chemokines responsible for the recruitment of monocytes. The proposed project will investigate if fibroblasts are responsible for the recruitment and differentiation of monocytes into lymphoid tissues following infection and how this impacts immune responses. For this, we will use a use a new animal model, viral infections, flow cytometry and confocal imaging. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Scott Mueller

Project Co-supervisor

Dr Yannick Alexandre

Project availability
Master of Biomedical Science

Mueller Group

6 vacancies

Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mueller group is focused on examining immune responses to acute and chronic viral infections and to tumours. We are using state-of-the-art methods, including intravital 2-photon microscopy, to visualise immune cells and pathogens in real time.

Mueller Group Current Projects