Project: Host-pathogen interactions of influenza B viruses
Influenza A and B viruses circulate annually during seasonal epidemics. Although influenza B viruses have a significant clinical and socio-economic impact, they have been overlooked compared to influenza A viruses. This project with utilise a combination of virology, molecular biology and reverse genetics techniques to understand the virus-host interactions of IBV in in vitro and in vivo models of infection. This project will allow a greater understanding of IBV evolution in humans.
Dr Marios Koutsakos and the Juno, Wheatley and Kent groups have an interest in understanding how the immune response can be harnessed in the control of infectious pathogens including SARS-CoV2, HIV, Mycobacterium tuberculosis and influenza. This includes understanding B cell responses, T-follicular helper cell responses and non-conventional T cell responses and how they are impacted by infection and vaccination.