Research Projects

Usually considered an extracellular pathogen, our group and others have shown that Staphylococcus aureus can also be an intracellular pathogen. Living in an intracellular niche enables S. aureus to evade antibiotic treatment and extracellular immune surveillance and help explain why some Staph infections are difficult to eradicate. This project will use a new high-throughput assay developed by our team called InToxSa, combined with genomics and computational approaches to give a molecular-level understanding of S. aureus within different host cell types such as macrophages, osteoblasts, epithelial and endothelial cells. The data from this project will allow us to find the molecular tricks used by the pathogen to cause lethal infections.

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