The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Harnessing the lymph nodes to treat cancer metastasis

Mueller Group

Metastasis is responsible for most cancer deaths, and new treatments are urgently needed against metastatic disease. Tumour cells use lymph nodes to spread around the body, but how this occurs is not clear. This project will examine how metastatic tumour cells corrupt lymph nodes and use this to spread. We will examine immune responses and stromal cells known as cancer associated fibroblasts to identify new ways to improve disease outcomes. Techniques used in this work include advanced spectral imaging and spectral flow cytometry, single cell RNA sequencing and spatial transcriptomics, custom imagage analysis tools and bioinformtics.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Scott Mueller

Project Co-supervisor

Dr Harry Horsnell

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Mueller Group

smue@unimelb.edu.au

5 vacancies

Themes
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mueller group is focused on examining immune responses and nervous system interactions during acute and chronic viral infections and in cancer. We are seeking a fundamental understanding of biology and new treatments for disease. We are using state-of-the-art methods, including advanced microscopy, spectral flow cytometry, single cell sequencing and bioinformatics.


Mueller Group Current Projects