The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Generation of protective immunity against severe influenza disease in Indigenous populations

Kedzierska group

Hospitalisation rates and mortality from influenza are increased in Indigenous populations, especially when new viruses emerge. There is a need for vaccines which generate immunity across distinct influenza strains and protect vulnerable populations. Long-lasting immunity can be elicited by killer T cells recognising conserved viral regions. However, T cell responses are restricted by an individual’s human leukocyte antigen (HLA) and specific HLA variants vary across ethnicities. Here, novel influenza T cell targets will be identified for HLA-A*1101, one of the most common HLAs in Indigenous and Asian populations. This project forms a part of a large-scale study aimed at designing and assembling a universal T cell-based influenza vaccine. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Katherine Kedzierska 

Project Co-supervisor

Dr Bridie Clemens, Luca Hensen 

Project availability
Master of Biomedical Science
Honours

Kedzierska group

[email protected]

2 vacancies

Themes
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Translational and Clinical Research
Discovery Research
Indigenous Health

The Kedzierska group has a strong international profile in human immunology, with a major focus on universal broadly-protective T cell immunity to seasonal, pandemic and avian influenza viruses. The main goals are to identify key correlates of severe and fatal influenza disease in high-risk groups, and to understand mechanisms underlying generation of optimal immunity to influenza viruses in young children, adults, the elderly, pregnant women, hospitalised patients and Indigenous Australians. Our studies intend to improve vaccine and therapeutic designs to protect against severe influenza, with possible applications to other infectious diseases and tumours. 


Kedzierska group Current Projects