The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Gamma delta T cells, crucial for malaria immunity

Heath Group

Plasmodium parasites which cause malaria are extremely complex pathogens, with a life cycle involving multiple stages within the mosquito vector and the human host. We have recently shown that gamma delta T cells are crucial to the generation of immunity to liver stage infection as without this cell population present, CD4 and CD8 T cell responses are severely impaired. We are dissecting the role that they play in this system using a combination of cellular assays including flow cytometry, histology and live intravital imaging.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Lynette Beattie

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Heath Group

lynette.beattie@unimelb.edu.au

3 vacancies

Themes
Immunology
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research

The Heath group is interested in the immune response to pathogens, particularly to malaria, which is still a major cause of mortality worldwide. We study T cell responses with the aim of improving vaccine strategies and focus on T cell responses in the skin, the liver and lymphoid organs including the spleen. Our lab recently discovered a population of resident memory T cells within the liver that are capable of protecting against malaria infection. These and other cells are currently being studied. 


Heath Group Current Projects