The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Finding the factors that make VRE such a successful hospital-adapted pathogen

Stinear Group

Enterococci emerged in terrestrial animals about 450 million years ago, and are frequent commensal bacteria in the human gut. In the past 50 years, pathogenic strains have emerged in our hospitals such as Enterococcus faecalis and Enterococcus faecium (VRE) that are highly persistent and resistant to multiple antibiotics. We have established a mouse model of VRE colonisation and RNAseq expression profiling to identify bacterial persistence factors. This project will apply molecular biology approaches to define factors essential for gut colonisation and persistence. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Tim Stinear, Professor Ben Howden

Project Co-supervisor

Dr Glen Carter

Project availability
Master of Biomedical Science

Stinear Group

[email protected]

2 vacancies

Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines

The Stinear group is full of fun-loving microbiologists who make mutants, uncover molecular mechanisms of pathogenesis, discover new antibiotics, make vaccines, create new diagnostic tests, track disease outbreaks, sequence bacterial genomes and expose dodgy science. Our research aims to understand bacterial pathogens in greater detail so that we can develop tools to detect, inhibit or control them. We collaborate with major hospitals and public health labs so that our research can be rapidly implemented and used to benefit society. 

Stinear Group Current Projects