The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Expanding the diversity of animal astroviruses through transcriptome mining

Howden Group

Astroviruses cause a number of diseases in humans and human astroviruses are responsible for 2-4% of endemic diarrhea worldwide. This virus family is also responsible for disease in food production animals, and small scale studies have strong suggested at a large undescribed diversity. Through interrogation of transcriptomic libraries in the Sequence Read Archive (SRA), a large diversity of Astroviruses are present and undescribed. This computation project will centre around annotation of Astroviruses in libraries of interest, such as those from birds and food production animals to substantially expand known virus diversity. Furthermore, through phylodynamic analysis, we may better understand the evolution of these viruses, and the risk for cross-species transmission events between the human:animal, and production animal: wildlife interfaces.

This is a computation project aimed at expanding the diversity of animal astroviruses. The first component will be mining the Sequence Read Archive (SRA) for previously undescribed Astroviruses, identified through serratus. The evolution of this virus family will be clarified through phylodynamic analysis

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Michelle Wille

Project Co-supervisor

Dr Celeste Donato

Project availability

Howden Group

2 vacancies

Antimicrobial Resistance
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Global Health
Indigenous Health

The Howden lab has a strong interest in understanding the various facets of antimcirobial resistance (AMR), spanning discovery research in AMR mechanisms and evolution through to translational projects to imporve AMR detection and surveillance, and treatment of resistant infections.