The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Engineering T cells to fight solid tumours

Mackay, Laura Group

Non-recirculating tissue-resident memory T (TRM) cells reside permanently in epithelial compartments where they are known to provide efficient protection against infection. TRM cells have recently been identified in various human cancers where they correlate with improved patient outcomes, but the mechanisms through which these cells mediate protective tumour immunity are unknown. This project aims to engineer Chimeric Antigen Receptor (CAR) T cells to infiltrate and persist within solid tumours. This work is essential to develop the capabilities to exploit the protective capacity of TRM cells for cancer immunotherapies.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Laura Mackay, Simone Park

Project availability
Honours

Mackay, Laura Group

[email protected]

1 vacancies

Themes
Immunology
Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mackay group has shown that specialised immune cells, called resident memory T cells, are critically important for protection against infection. These immune cells live in body tissues, where they stand guard at sites of pathogen invasion to directly combat infection. Within the Mackay lab, we aim to greatly enhance our fundamental understanding of resident memory T cell biology, and how these cells protect against disease. By learning to control these immune cells we can harness their protective function, with the ultimate goal of translating our basic discovery research into novel treatments for infectious disease, cancer and autoimmune disease. 


Mackay, Laura Group Current Projects