The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Development of novel proteomic tools to explore Burkholderia glycosylation dependent pathogenesis

Scott group

Bacterial protein glycosylation, once thought to be a rare event, has now been shown to be widespread. To date, multiple general glycosylation systems have been identified yet the precise role in bacterial physiology are still unknown. A common theme is the requirement of glycosylation for persistence and virulence in mammalian hosts. Within this project, we aim to explore the role of glycosylation in Burkholderia species virulence in the mammalian host. By coupling recent innovations in metabolic labelling, redox probes and mass spectrometry workflows we seek to explore how glycosylation influence intracellular survival to increase our understanding of the molecular pathogenesis of Burkholderia. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Nichollas Scott

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Scott group

[email protected]

2 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research

The Scott group focuses on the identification and characterisation microbial mediate protein glycosylation. This post translational modification allows pathogens to radically alter the function of proteins both within them, and their hosts. Within a range of pathogens such as malaria and Burkholderia, microbial protein glycosylation is used for both defensive and offensive processes, enabling pathogens to fortify themselves against the host immune response or to disarm the host’s ability to resist infection. Using mass spectrometry-based approaches, the Scott group seeks to develop methodologies to identify and track microbial glycosylation events to understand how microbes remodel their proteome and that of the hosts. 


Scott group Current Projects