Project: Deep learning approaches to track immune cell migration in vivo
Mueller Group
We have developed a world-leading intravital 3-photon microscope to investigate how immune cells behave in vivo. The technique generates 4D timelapse data (3D in space, 1D in time), which enables us to visualise the dense 3D tissue environment and the migratory behavior of individual immune cells within. We have also developed and patented a novel method that allows us to track individual immune cells in the eyes of living humans, opening up exciting opportunities for generating human-relevant and clinically relevant insights on immune cell behaviors. However, quantitative analysis of immune cells dynamics in these complex tissue microenvironments is limited by a lack of accurate and reliable cell segmentation options for complex, time-lapse images. In this project, we will develop novel deep learning approaches to improve the segmentation and analysis of immune cell behaviours, and their interactions with other cells and structures, in living mouse tissues and human eyes.
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Mueller Group
5 vacancies
Research in the Mueller group is focused on examining immune responses and nervous system interactions during acute and chronic viral infections and in cancer. We are seeking a fundamental understanding of biology and new treatments for disease. We are using state-of-the-art methods, including advanced microscopy, spectral flow cytometry, single cell sequencing and bioinformatics.
Mueller Group Current Projects
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Neural regulation of anti-cancer immunity
PhD/MPhil, Master of Biomedical Science, Honours
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Harnessing the lymph nodes to treat cancer metastasis
PhD/MPhil, Master of Biomedical Science, Honours
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Targeting stem-like T cell niches to treat chronic infections
PhD/MPhil, Master of Biomedical Science, Honours
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New ways of targeting monocytes to treat infection and cancer
PhD/MPhil, Master of Biomedical Science, Honours
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Neuroimmune interactions in virus infection
PhD/MPhil, Master of Biomedical Science
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Deep learning approaches to track immune cell migration in vivo
PhD/MPhil
Research degrees at the Doherty Institute are administered by the University of Melbourne.