The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Deep learning approaches to track immune cell migration in vivo

Mueller Group

We have developed a world-leading intravital 3-photon microscope to investigate how immune cells behave in vivo. The technique generates 4D timelapse data (3D in space, 1D in time), which enables us to visualise the dense 3D tissue environment and the migratory behavior of individual immune cells within. We have also developed and patented a novel method that allows us to track individual immune cells in the eyes of living humans, opening up exciting opportunities for generating human-relevant and clinically relevant insights on immune cell behaviors. However, quantitative analysis of immune cells dynamics in these complex tissue microenvironments is limited by a lack of accurate and reliable cell segmentation options for complex, time-lapse images. In this project, we will develop novel deep learning approaches to improve the segmentation and analysis of immune cell behaviours, and their interactions with other cells and structures, in living mouse tissues and human eyes. 

Contact project supervisor for further
information and application enquiries

Project Supervisor

Professor Scott Mueller

Project Co-supervisor

A/Prof Vijay Rajagopal

Prof Laura Downie

Project availability

Mueller Group

5 vacancies

Viral Infectious Diseases
Cross Cutting Disciplines
Discovery Research

Research in the Mueller group is focused on examining immune responses and nervous system interactions during acute and chronic viral infections and in cancer. We are seeking a fundamental understanding of biology and new treatments for disease. We are using state-of-the-art methods, including advanced microscopy, spectral flow cytometry, single cell sequencing and bioinformatics.

Mueller Group Current Projects