The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Characterisation of antimicrobial resistance and virulence of novel staphylococcal lineages

Tong Group

We have recently described emerging lineages of Staphylococcus aureus and Staphylococcus argenteus in northern Australia. The ST5 Staphylococcus aureus lineage has acquired resistance to trimethoprim and appears to have a clinically virulent phenotype. This project will determine the likelihood and mechanism of generation of resistance to co-trimoxazole (a commonly used antibiotic) and the virulence of this ST5 clone in relation to other Staphylococcus aureus clones. For Staphylococcus argenteus, we have identified a lineage associated with invasive infections and seek to identify genomic elements that confer this phenotype.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Associate Professor Steven Tong

Project Co-supervisor

Professor Benjamin Howden

Project availability
PhD/MPhil
Honours

Tong Group

steve[email protected]

2 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Cross Cutting Disciplines
Translational and Clinical Research
Epidemiology
Genomics
Indigenous Health
Public Health

The Tong group encompasses a multi-disciplinary group crossing bacterial and viral genomics, epidemiology, Indigenous health and clinical trials. We are committed to improving Indigenous health with partners in northern Australia, and developing capacity for conducting multi-centre clinical trials using novel methodologies. At the Doherty Institute, we collaborate extensively with the epidemiology and mathematical modelling groups, and the Doherty Applied Microbial Genomics team.