The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Bacterial pan-genome graphs for variant discovery and RNAseq for drug resistance prediction

Coin Group

This project aims to construct comprehensive bacterial pan-genome graphs to facilitate variant discovery and RNA-seq analysis. By integrating diverse genomic data from multiple bacterial strains, we will develop a unified pan-genome representation that captures the full genetic diversity of the species. Leveraging the pan-genome graph for RNA-seq analysis will enhance our understanding of gene expression and regulation in different bacterial genetic backgrounds. This project holds the potential to uncover novel insights into bacterial adaptation, virulence, and antibiotic resistance mechanisms.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Prof Lachlan Coin

Project Co-supervisor

Dr Michael Hall

Project availability

Coin Group

3 vacancies

Viral Infectious Diseases
Antimicrobial Resistance
Bacterial and Parasitic Infections
Cross Cutting Disciplines
Discovery Research
Computational Science and Genomics
Clinical and health systems research

The Coin group applies genomic sequencing to characterise and understand the dynamics of  human and bacterial genomics and transcriptomics. We utilise long-read, real-time sequencing for detection and characterization of bacterial pathogens direct from samples, and are leaders in the development of host immune response biomarkers for detection of bacterial and viral infections.We develop and use algorithmic approaches for analysis of high throughput sequence data.