The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital


Research Projects

Project: Are there additional MAIT cell antigens?

McCluskey group

Our team identified the known natural MAIT cell antigens, small molecule antigens which derive from microbial riboflavin biosynthesis. We seek to further understand how these antigens are produced and whether other antigens exist. We have preliminary data for three projects on MAIT cell antigen discovery that we are happy to discuss in detail in person. Broadly speaking, MAIT cell antigen discovery involves in vitro cell line model systems, human blood cell assays, flow cytometry, microbial culture and our proven protein-folding/mass-spectrometry approach.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Sidonia Eckle, Dr Lars Kjer-Nielsen, Dr Alexandra Corbett

Project availability

McCluskey group

4 vacancies

Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Translational and Clinical Research

The McCluskey group is an internationally-leading laboratory in mucosal-associated invariant T (MAIT) cell research, having made significant breakthrough discoveries in MAIT cell immunity. These include identifying the antigens recognised by MAIT cells and the associated development of tetramers to characterise MAIT cells (patented). The McCluskey group has also developed human in vitro and in vivo models to understand MAIT cell function and the role of MAIT cells as part of the immune system. In addition, the group has deep expertise in biochemistry, including MAIT cell ligand discovery by mass spectrometry and cellular immunology, allowing to comprehensively address big picture research questions.