The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Application of systems genomics to analysing the dynamics of Streptococcus pyogenes infection

Davies Group

The relationship between, and integration of, genomics, transcriptomics, proteomics and metabolomics lies at the heart of understanding how organisms, including bacteria, respond to environmental changes and especially stress, be it physical, immunological or nutritional. This is generically termed systems biology. This project will examine the systems biology of Streptococcus pyogenes subject to a major and important stress, transition from the ex vivo environment to blood. The research will use various aspects of molecular biology and especially bioinformatics to address the key research questions. Avenues are available to expand this research into looking at immunogenetics within a controlled human infection.

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Mark Davies

Project availability
PhD/MPhil
Honours

Davies Group

[email protected]

3 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research
Genomics
Indigenous Health
Public Health

The Davies group aims to apply genome sequencing methodologies and bioinformatics approaches to understand the evolution and transmission of bacterial pathogens. This knowledge can help facilitate a global understanding of pathogen evolution, in addition to informing public health intervention to reduce the disease burden associated with bacterial pathogens. Current projects address key research questions such as: is there a genetic difference between strains causing different disease manifestations? What is driving the emergence and dissemination of bacterial pathogens? Do host immune factors govern disease severity? Our research closely aligns with key international collaborators including the Wellcome Trust Sanger Institute in the United Kingdom.