Project: Application of proteomics to explore Burkholderia pathogenesis
Scott group
Within this project, we aim to explore new state of the art approaches to track and quantify proteomic changes at the intracellular host pathogen interface. Utilising proteomics we will characterise both the host and bacterial factors which shape pathogenesis. By gaining insight into how Burkholderia species, such as Burkholderia cenocepacia (a serious opportunistic infection of CF sufferers), survives within human cells this will provide a deeper understanding of the molecular pathogenesis of Burkholderia infections.
Proteomics & Burkholderia pathogenesis
Contact project supervisor for further
information and application enquiries
Scott group
4 vacancies
The Scott Group focuses on the application of molecular microbiology and mass spectrometry (MS)-based methodologies to characterise microbial systems. The key focus of the lab is understanding how pathogens of the Burkholderia genus cause disease and why proteins decorated with carbohydrates influence Burkholderia pathogenesis.
Projects within the Scott lab: Two broad projects are currently on offer in the Scott lab; Project 1 involves using proteomics and CRISPRi based approaches to understand which glycoproteins are preferentially glycosylated within Burkholderia cenocepacia. Project 2 involves using proteomics to study the impact of Burkholderia cenocepacia infections on Eukaryotic cells using a combination of proteomics approaches.
Scott group Current Projects
-
Application of proteomics to explore Burkholderia pathogenesis
PhD/MPhil, Master of Biomedical Science, Honours
-
Monitoring O-linked glycosylation dynamics within Burkholderia cenocepacia
PhD/MPhil, Master of Biomedical Science, Honours
-
Turning a conserved system bad; Understanding how alterations within O-linked glycosylation biosynthesis results in toxicity in Burkholderia cenocepacia
PhD/MPhil, Master of Biomedical Science, Honours
-
Understanding the role of protein glycosylation within Acinetobacter baumannii
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.