The Univeristy of Melbourne The Royal Melbourne Hopspital

A joint venture between The University of Melbourne and The Royal Melbourne Hospital

EDUCATION

Research Projects

Project: Application of proteomics to explore Burkholderia pathogenesis

Scott group

Within this project, we aim to explore new state of the art approaches to track and quantify proteomic changes at the intracellular host pathogen interface. Utilising proteomics we will characterise both the host and bacterial factors which shape pathogenesis. By gaining insight into how Burkholderia species, such as Burkholderia cenocepacia (a serious opportunistic infection of CF sufferers), survives within human cells this will provide a deeper understanding of the molecular pathogenesis of Burkholderia infections.

Proteomics & Burkholderia pathogenesis

Contact project supervisor for further
information and application enquiries

Project Supervisor

Dr Nichollas Scott

Project availability
PhD/MPhil
Master of Biomedical Science
Honours

Scott group

nichollas.scott@unimelb.edu.au

2 vacancies

Themes
Antimicrobial Resistance and Healthcare Associated Infections
Host Pathogens Interactions
Cross Cutting Disciplines
Discovery Research

The Scott Group focuses on the application of molecular microbiology and mass spectrometry (MS)-based methodologies to characterise microbial systems. The key focus of the lab is understanding how pathogens of the Burkholderia genus cause disease and why proteins decorated with carbohydrates influence Burkholderia pathogenesis.

Projects within the Scott lab: Two broad projects are currently on offer in the Scott lab; Project 1 involves using proteomics and CRISPRi based approaches to understand which glycoproteins are preferentially glycosylated within Burkholderia cenocepacia. Project 2 involves using proteomics to study the impact of Burkholderia cenocepacia infections on Eukaryotic cells using a combination of proteomics approaches.


Scott group Current Projects