Project: Antibodies preventing HTLV-1c infection
Purcell Group
The HTLV-1c virus is mostly spread by cell-cell contact with infected T-lymphocytes at the sexual mucosae or following blood exposure. Nevertheless, neutralising antibodies have been reported to block virus transmission. We have engineered and expressed soluble HTLV-1c Env trimers and with these, have developed assays that measure the potency and breadth of HTLV-1c neutralising antibody in patient serum. This project will seek to produce monoclonal antibody NAbs against HTLV-1c Env trimers for development of a passive immunotherapy strategy to prevent HTLV transmission. We will also examine the potential of HTLV-1c Env trimers as a candidate preventive vaccine in mice vaccinated with them.
Contact project supervisor for further
information and application enquiries
Purcell Group
5 vacancies
Professor Damian Purcell’s group investigates the HIV-1 and HTLV-1 human retroviruses that cause AIDS, leukaemia and inflammatory pathogenesis respectively. We study their genetic structure and gene expression with a focus on defining the mechanisms that control viral persistence and pathogenesis. We examine the molecular interplay of viral and host factors during viral infection and the innate and adaptive immune responses to viral infection. We use these molecular insights to develop new antiviral and curative therapeutics, preventive prophylactic vaccines and passive antibody microbicides and therapeutics. Some of these patented discoveries have been commercialised and we are assisting with clinical trials.
Purcell Group Current Projects
-
RNA control of HIV latency
PhD/MPhil, Master of Biomedical Science
-
New drugs to reactivate latent HIV
PhD/MPhil, Master of Biomedical Science
-
Pathogenesis of HTLV-1 subtype-C infecting remote indigenous Australians
PhD/MPhil, Master of Biomedical Science, Honours
-
Antibodies preventing HTLV-1c infection
PhD/MPhil, Master of Biomedical Science, Honours
-
SARS-CoV-2 escape from neutralising antibody control
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.