Project: A new transcription factor for lymph node homeostasis
Mueller Group
Lymph nodes are critical for immune responses. Within lymph nodes, specialised fibroblasts construct and support the tissue by defining distinct compartments and providing signals that can either promote or inhibit immune responses. We recently identified a new transcription factor required that support the differentiation and homeostatic functions of these fibroblasts, and regulate antiviral T cell responses. This project will investigate how this novel transcription factor regulates lymph node homeostasis and the initiation of immune responses to infection. For this, we will use a use a new animal model, flow cytometry and confocal imaging.
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Mueller Group
6 vacancies
Research in the Mueller group is focused on examining immune responses to acute and chronic viral infections and to tumours. We are using state-of-the-art methods, including intravital 2-photon microscopy, to visualise immune cells and pathogens in real time.
Mueller Group Current Projects
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Regeneration of lymphoid tissues
Master of Biomedical Science, Honours
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Neural regulation of anti-cancer immunity
PhD/MPhil, Master of Biomedical Science, Honours
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How do lymph nodes facilitate cancer metastasis?
PhD/MPhil, Master of Biomedical Science, Honours
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Lymphoid tissues and regulation of T cell responses to chronic viral infection
PhD/MPhil, Master of Biomedical Science, Honours
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How do fibroblasts regulate immune response during infection?
PhD/MPhil, Master of Biomedical Science
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A new transcription factor for lymph node homeostasis
PhD/MPhil, Master of Biomedical Science, Honours
Research degrees at the Doherty Institute are administered by the University of Melbourne.