Researchers at the Doherty Institute are engaged in broad clinical research efforts related to tuberculosis (TB) disease, management and elimination. There is an active program of population health and mathematical modelling research assisting with evaluation of effective and ethical TB strategies both in Australia and internationally. In parallel, basic research on TB includes understanding the TB genome and the body’s immune response to TB. These activities are strengthened by a range of state-wide services for public health management of TB provided at the Doherty Institute including clinical care, epidemiology, contact tracing and rapid diagnosis of infection and drug resistance. The close collaboration amongst groups with complementary expertise means that the Doherty Institute is an exciting environment for developing and implementing novel, high-impact strategies towards better TB care and global elimination of this disease.