The Doherty Institute combines discovery science and clinical research to improve health outcomes, with a focus on the prevention, diagnosis and treatment of infectious diseases globally through the translation of basic scientific discoveries into clinical practice.
Translational and clinical research at the Doherty Institute ranges from interventional and observational studies, to laboratory studies and are mostly multi-centre and investigator lead, with some industry-sponsored studies.
Research currently being undertaken at the Doherty Institute includes:
- Interventional trials to identify cost effective treatment for latent tuberculosis
- Determining the impact of the drug, dolutegravir, on residual replication in HIV
- Evaluating the safety of treatments in HIV-hepatitis C co-infected patients with bleeding disorders
Researchers are also conducting a number of observational studies in influenza, HIV, malaria, hepatitis, tuberculosis, dengue and fungal infections, with both local and far reaching impact. Studies of influenza range from severe influenza in indigenous Australians, to newly emerging influenza viruses in China. In HIV, observational studies span the impact of stem cell transplantation on HIV reservoirs, to liver disease in HIV-hepatitis B virus co-infected patients in Thailand. In dengue, an international, multi-centre study is identifying risk factors for severe disease in six countries, while mosquito biting behaviour and repellents are being investigated in dengue patients in Vietnam.